Van Andel Institute’s Dr. Nick Burton Honored as 2025 Pew Scholar in Biomedical Sciences

In a significant recognition of scientific promise and innovation, Dr. Nick Burton of the Van Andel Institute (VAI) has been named a 2025 Pew Scholar in the Biomedical Sciences. This prestigious accolade by The Pew Charitable Trusts celebrates early-career researchers who demonstrate boldness, creativity, and a commitment to advancing human health through cutting-edge biomedical research. Out of 209 highly competitive nominations, only 22 scientists, including Burton, were selected to join this esteemed community for the next four years.

The Pew Scholars program, established over four decades ago, consistently fosters the growth of talented young scientists who approach intricate biomedical challenges with novel methodologies and interdisciplinary perspectives. Donna Frisby-Greenwood, Pew’s senior vice president for Philadelphia and scientific advancement, emphasized the enduring legacy of this award: “For 40 years, Pew has supported young, talented researchers as they take creative approaches to solving big scientific questions. This new class continues that legacy, and we look forward to seeing where their discoveries lead.”

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Dr. Burton’s research uniquely positions him at the intersection of environmental biology, developmental programming, and microbial ecology. His focus lies in understanding how complex environmental factors, such as stress and microbial exposure, modulate human health outcomes across generations. This pioneering approach draws heavily on the developmental origins of health and disease (DOHaD) hypothesis, which posits that environmental influences during critical windows of development—particularly prenatal and early postnatal periods—can have lasting effects on physiology, disease susceptibility, and metabolic function.

Central to Burton’s laboratory is the investigation of how ambient environmental microbes may exert epigenetic and immunological effects on offspring, potentially altering their vulnerability to metabolic disorders. This work involves sophisticated genomic and metabolomic profiling techniques to unravel the molecular mechanisms that mediate host-microbe interactions in both maternal and fetal tissues. His research also extends to the biochemical characterization of microbial byproducts, illuminating how symbiotic relationships with environmental bacteria can influence metabolic signaling pathways.

A particularly innovative facet of Burton’s research is his exploration of soil-derived bacteria as a source of novel therapeutic agents, specifically for Type 2 diabetes. The rationale for this approach is grounded in the historic success of microbe-derived medicines, from antibiotics to immunosuppressive drugs. By applying advanced bioinformatics and chemical biology tools, his team screens microbial metabolites for bioactivity that could modulate insulin sensitivity, glucose metabolism, or inflammatory responses characteristic of diabetes pathology. Such work not only holds translational potential but also exemplifies the convergence of environmental microbiology and metabolic disease research.

Burton’s academic journey reflects a trajectory dedicated to excellence and interdisciplinary inquiry. Having earned his Ph.D. from the Massachusetts Institute of Technology and completed a prestigious Next Generation Fellowship at the University of Cambridge’s Centre for Trophoblast Research, he brought a wealth of knowledge to VAI upon joining as an assistant professor in the Department of Metabolism and Nutritional Programming in 2021. His work embodies the philosophy that understanding metabolism requires integrating nutritional science, molecular biology, and environmental exposures.

The scientific community stands to benefit greatly from the fresh perspectives Burton contributes. His approach aligns with a broader shift in biomedical research that recognizes the microbiome and environmental context as critical determinants of health. Incorporating techniques like high-throughput sequencing, metabolomics, and advanced computational modeling, his investigations aim to delineate the complex networks linking environment, microbial ecology, host development, and chronic disease.

This four-year Pew award will provide Burton with crucial resources to expand the scope and depth of his investigations. It will also connect him to a vibrant network of scholars who, over the past 35 years, have driven transformative advances in cancer biology, neuroscience, immunology, and beyond. The grant encourages recipients to pursue high-risk, high-reward research that challenges existing paradigms and accelerates biomedical innovation.

Beyond the laboratory, Burton expresses a profound appreciation for the opportunity to collaborate with fellow Pew Scholars. “I’m grateful to The Pew Charitable Trusts for the opportunity to be part of such an excellent community of scientists,” he said. “Pew Scholars pursue bold, innovative ideas to improve health, and I’m thrilled to join them.” This sentiment highlights the crucial role of scientific networks in fostering interdisciplinary dialogue and catalyzing breakthroughs.

The Van Andel Institute itself is recognized as a hub of scientific discovery, committed to unearthing the biological mechanisms behind cancer, Parkinson’s disease, and other major health challenges. VAI emphasizes translational research with the goal of developing novel prevention and treatment modalities. Burton’s affiliation with this forward-thinking institution underscores the alignment between his research vision and the Institute’s mission to improve health outcomes through molecular and cellular biology.

As interest grows in how environmental factors shape metabolic diseases and developmental health, Dr. Burton’s research stands at the forefront of an emerging field with broad public health implications. His efforts not only promise advances in understanding and treating Type 2 diabetes but also foster a nuanced appreciation for the complex interplay between humans and their microbial environments.

The recognition by The Pew Charitable Trusts marks not only a personal achievement for Burton but also highlights the increasing importance of research on environmental contributions to human health. As scientific inquiry continues to unravel these intricate relationships, it is researchers like Burton who pave the way for innovative therapies and preventive strategies that transcend traditional biomedical boundaries.

Subject of Research: Developmental programming, environmental microbiology, metabolic health, Type 2 diabetes therapies
Article Title: Van Andel Institute’s Dr. Nick Burton Named 2025 Pew Scholar in Biomedical Sciences
News Publication Date: August 12, 2025
Web References:

https://www.pew.org/en/about/news-room/press-releases-and-statements/2025/08/12/pew-awards-22-researchers-biomedical-science-grants

Burton Laboratory

Could backyard bacteria and hungry worms help solve a central problem in Type 2 diabetes?

http://www.vai.org/
Image Credits: Courtesy of Van Andel Institute
Keywords: Metabolic health, Environmental microbiology, Developmental programming, Type 2 diabetes, Biomedical research, Microbial metabolites

Tags: advancing human health researchcreative problem-solving in scienceDr. Nick Burtonearly-career scientific researchersenvironmental biology and healthinnovative biomedical researchinterdisciplinary scientific approachesmicrobial ecology studiesPew Scholar in Biomedical Sciences 2025prestigious scientific awardsselection for Pew Scholars programVan Andel Institute